Gary Birnbaum, MD
CAR-T cells-A new treatment for MS? Or maybe not.
A CAR-T therapy for multiple sclerosis enters US trials for first time Asher Mullard Nature, 22 February 2024 https://www.ncbi.nlm.nih.go...
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Gary Birnbaum, MD
Dec 3, 20215 min read
Hydroxychloroquine as treatment for progressive multiple sclerosis? Maybe!
Hydroxychloroquine for Primary Progressive Multiple Sclerosis Marcus W Koch, Sharanjit Kaur, Kayla Sage, Janet Kim, Myriam Levesque-Roy,...
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Gary Birnbaum, MD
Oct 20, 20213 min read
I have MS and wish to become pregnant. Now what?
Treatment of Women with Multiple Sclerosis Planning Pregnancy Krysko, K. M., Bove, R., Dobson, R., Jokubaitis, V. Hellwig, K. Curr Treat...
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Gary Birnbaum, MD
Aug 16, 20215 min read
Predicting Progression: Identifying Risks for Transition to Progressive Disease
A novel prognostic score to assess the risk of progression in relapsing−remitting multiple sclerosis patients Anna Isabella Pisani,...
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Gary Birnbaum, MD
Apr 28, 20215 min read
Aging and MS - Not easy for anyone
Multiple sclerosis and aging: comorbidity and treatment challenges Aiora Ostolaza *, Jon Corroza, Teresa Ayuso Multiple Sclerosis and...
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Gary Birnbaum, MD
Apr 4, 20216 min read
A vaccine to treat MS? Not now but ..........
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis Christina Krienke, Laura Kolb, Elif Diken et al...
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Gary Birnbaum, MD
Jan 30, 20215 min read
Oxygen for MS?
Bottom Line: Multiple sclerosis is a heterogeneous disease. It is, in my opinion, a syndrome like pneumonia, that is an illness with...
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Gary Birnbaum, MD
Dec 29, 20206 min read
A novel but possible approach for preventing COVID-19
Paper #1: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, et al. Science 370,...
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Gary Birnbaum, MD
Oct 29, 20205 min read
One DMT may not be enough
Paper #1: Silent Progression in Disease Activity–Free Relapsing Multiple Sclerosis University of California, San Francisco MS-EPIC Team,...
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Gary Birnbaum, MD
Aug 13, 20207 min read
A most important observation!
Bottom Line: Recent work in persons with MS suggests that the gut microbiome (the population of bacteria in the gut) is altered in MS,...
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Gary Birnbaum, MD
Jul 3, 20209 min read
Yes? No? Maybe? Making treatment decisions during the coronavirus pandemic
A list of summarized articles is at the end of this posting. Bottom Line: There are at least four critical questions that persons with MS...
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Gary Birnbaum, MD
Feb 23, 20206 min read
RIS: To treat or not to treat, that is the question
Treatment Considerations in the Radiologically Isolated Syndrome. Makhani N. Curr Treat Options Neurol. 2020;22:3....
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Gary Birnbaum, MD
Dec 19, 20195 min read
Avoiding Disease Rebound
Rebound of multiple sclerosis activity after fingolimod withdrawal due to planning pregnancy: Analysis of predisposing factors. Sepulveda...
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Gary Birnbaum, MD
Apr 29, 20194 min read
D for all MS?
The Association Between Vitamin D and Multiple Sclerosis Risk: 1,25(OH)2D3 Induces Super-Enhancers Bound by VDR Ming Lu, Bennet J....
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Gary Birnbaum, MD
Feb 17, 20193 min read
A double-edged sword
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi...
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Gary Birnbaum, MD
Jan 23, 20196 min read
Can progressive MS be prevented?
Brown JWL, Coles A, Horakova D, Havrdova E, et al. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary...
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Gary Birnbaum, MD
Jan 23, 20194 min read
Dealing with MS+, and how to minimize it
Van Dyken P, Lacoste B. Impact of Metabolic Syndrome on Neuroinflammation and the Blood-Brain Barrier. Front Neurosci. 2018;12:930. Key...
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Gary Birnbaum, MD
Jan 23, 20193 min read
Understanding ways to promote healing in MS
Lu G, Zhang M, Wang J, Zhang K, Wu S, Zhao X. Epigenetic regulation of myelination in health and disease. Eur J Neurosci. 2019. Key...
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Gary Birnbaum, MD
Jan 23, 20194 min read
A potential new treatment for MS
Carty M, Bowie AG. SARM: from immune regulator to cell executioner. Biochem Pharmacol. 2019. Key Points: a) Central nervous system...
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