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    Hydroxychloroquine as treatment for progressive multiple sclerosis? Maybe!
    Gary Birnbaum, MD
    • Dec 3, 2021
    • 5 min

    Hydroxychloroquine as treatment for progressive multiple sclerosis? Maybe!

    Hydroxychloroquine for Primary Progressive Multiple Sclerosis Marcus W Koch, Sharanjit Kaur, Kayla Sage, Janet Kim, Myriam Levesque-Roy,...
    57 views0 comments
    I have MS and wish to become pregnant. Now what?
    Gary Birnbaum, MD
    • Oct 20, 2021
    • 3 min

    I have MS and wish to become pregnant. Now what?

    Treatment of Women with Multiple Sclerosis Planning Pregnancy Krysko, K. M., Bove, R., Dobson, R., Jokubaitis, V. Hellwig, K. Curr Treat...
    75 views0 comments
    Predicting Progression: Identifying Risks for Transition to Progressive Disease
    Gary Birnbaum, MD
    • Aug 16, 2021
    • 5 min

    Predicting Progression: Identifying Risks for Transition to Progressive Disease

    A novel prognostic score to assess the risk of progression in relapsing−remitting multiple sclerosis patients Anna Isabella Pisani,...
    56 views0 comments
    Aging and MS - Not easy for anyone
    Gary Birnbaum, MD
    • Apr 28, 2021
    • 5 min

    Aging and MS - Not easy for anyone

    Multiple sclerosis and aging: comorbidity and treatment challenges Aiora Ostolaza *, Jon Corroza, Teresa Ayuso Multiple Sclerosis and...
    106 views0 comments
    A vaccine to treat MS? Not now but ..........
    Gary Birnbaum, MD
    • Apr 4, 2021
    • 6 min

    A vaccine to treat MS? Not now but ..........

    A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis Christina Krienke, Laura Kolb, Elif Diken et al...
    108 views0 comments
    Oxygen for MS?
    Gary Birnbaum, MD
    • Jan 30, 2021
    • 5 min

    Oxygen for MS?

    Bottom Line: Multiple sclerosis is a heterogeneous disease. It is, in my opinion, a syndrome like pneumonia, that is an illness with...
    83 views0 comments
    A novel but possible approach for preventing COVID-19
    Gary Birnbaum, MD
    • Dec 29, 2020
    • 6 min

    A novel but possible approach for preventing COVID-19

    Paper #1: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, et al. Science 370,...
    80 views0 comments
    One DMT may not be enough
    Gary Birnbaum, MD
    • Oct 29, 2020
    • 5 min

    One DMT may not be enough

    Paper #1: Silent Progression in Disease Activity–Free Relapsing Multiple Sclerosis University of California, San Francisco MS-EPIC Team,...
    77 views0 comments
    A most important observation!
    Gary Birnbaum, MD
    • Aug 13, 2020
    • 7 min

    A most important observation!

    Bottom Line: Recent work in persons with MS suggests that the gut microbiome (the population of bacteria in the gut) is altered in MS,...
    109 views0 comments
    Yes? No? Maybe? Making treatment decisions during the coronavirus pandemic
    Gary Birnbaum, MD
    • Jul 3, 2020
    • 9 min

    Yes? No? Maybe? Making treatment decisions during the coronavirus pandemic

    A list of summarized articles is at the end of this posting. Bottom Line: There are at least four critical questions that persons with MS...
    224 views0 comments
    RIS: To treat or not to treat, that is the question
    Gary Birnbaum, MD
    • Feb 23, 2020
    • 6 min

    RIS: To treat or not to treat, that is the question

    Treatment Considerations in the Radiologically Isolated Syndrome. Makhani N. Curr Treat Options Neurol. 2020;22:3....
    130 views0 comments
    Avoiding Disease Rebound
    Gary Birnbaum, MD
    • Dec 20, 2019
    • 5 min

    Avoiding Disease Rebound

    Rebound of multiple sclerosis activity after fingolimod withdrawal due to planning pregnancy: Analysis of predisposing factors. Sepulveda...
    245 views0 comments
    D for all MS?
    Gary Birnbaum, MD
    • Apr 29, 2019
    • 4 min

    D for all MS?

    The Association Between Vitamin D and Multiple Sclerosis Risk: 1,25(OH)2D3 Induces Super-Enhancers Bound by VDR Ming Lu, Bennet J....
    84 views0 comments
    A double-edged sword
    Gary Birnbaum, MD
    • Feb 17, 2019
    • 3 min

    A double-edged sword

    Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi...
    45 views0 comments
    Can progressive MS be prevented?
    Gary Birnbaum, MD
    • Jan 23, 2019
    • 6 min

    Can progressive MS be prevented?

    Brown JWL, Coles A, Horakova D, Havrdova E, et al. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary...
    39 views0 comments
    Dealing with MS+, and how to minimize it
    Gary Birnbaum, MD
    • Jan 23, 2019
    • 4 min

    Dealing with MS+, and how to minimize it

    Van Dyken P, Lacoste B. Impact of Metabolic Syndrome on Neuroinflammation and the Blood-Brain Barrier. Front Neurosci. 2018;12:930. Key...
    41 views0 comments
    Understanding ways to promote healing in MS
    Gary Birnbaum, MD
    • Jan 23, 2019
    • 3 min

    Understanding ways to promote healing in MS

    Lu G, Zhang M, Wang J, Zhang K, Wu S, Zhao X. Epigenetic regulation of myelination in health and disease. Eur J Neurosci. 2019. Key...
    33 views0 comments
    A potential new treatment for MS
    Gary Birnbaum, MD
    • Jan 23, 2019
    • 4 min

    A potential new treatment for MS

    Carty M, Bowie AG. SARM: from immune regulator to cell executioner. Biochem Pharmacol. 2019. Key Points: a) Central nervous system...
    44 views0 comments

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