Disease pathology

Changing Insights Demand Change

New insights in MS challenge current concept of disease categorization

Gary Birnbaum, MD

Apr 8, 20236 min read

Why does MS vary in severity? A very important new clue!

The Genetic Basis of Multiple Sclerosis Severity Suggests Central Nervous System Involvement A. Harroud, on behalf of the...

Gary Birnbaum, MD

May 26, 20224 min read

Can this virus really cause MS?

Paper #1: Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis Kjetil Bjornevik,...

Gary Birnbaum, MD

Mar 18, 20227 min read

Turning MS inside out!

Paper #1 - Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter Antonio Luchicchi, PhD, Bert’t Hart, PhD, Irene...

Gary Birnbaum, MD

Mar 20, 20218 min read

Oxygen for MS?

Bottom Line: Multiple sclerosis is a heterogeneous disease. It is, in my opinion, a syndrome like pneumonia, that is an illness with...

Gary Birnbaum, MD

Jan 30, 20215 min read

Can pregnancy help solve some of the mysteries of MS?

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis Ramien C, Yusko EC, Engler JB, Gamradt S, Patas K, Schweingruber...

Gary Birnbaum, MD

Oct 31, 20196 min read

Can one predict the course of MS?

Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS Sinah Engel,* Michaela...

Gary Birnbaum, MD

Sep 21, 20196 min read

Can a "silent" virus infection trigger MS?

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice Steinbach, K., Vincenti, I., Egervari, K....

Gary Birnbaum, MD

Aug 11, 20194 min read

Making MS personal

POST-MORTEM MULTIPLE SCLEROSIS LESION PATHOLOGY IS INFLUENCED BY SINGLE NUCLEOTIDE POLYMORPHISMS Nina L. Fransen, Jakob B.A. Crusius,...

Gary Birnbaum, MD

Jul 15, 20193 min read

Identical but not!

DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis. Nicole Y. Souren, Lisa A. Gerdes, Pavlo...

Gary Birnbaum, MD

Jun 14, 20194 min read

Inside-Out or Outside-In?

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Jianqin Niu, Hui-Hsin Tsai,...

Gary Birnbaum, MD

May 16, 20193 min read

Dating Brain Cells

Dynamics of oligodendrocyte generation in multiple sclerosis Maggie S. Y. Yeung, Mehdi Djelloul, Embla Steiner, Samuel Bernard, Mehran...

Gary Birnbaum, MD

Feb 7, 20194 min read

Understanding ways to promote healing in MS

Lu G, Zhang M, Wang J, Zhang K, Wu S, Zhao X. Epigenetic regulation of myelination in health and disease. Eur J Neurosci. 2019. Key...

Gary Birnbaum, MD

Jan 23, 20193 min read