Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis. Qin, C., Dong, M-H, Zhou, L-H et al. Cell 188 , 6414–6423 e6411 (2025) https://www.ncbi.nlm.nih.gov/pubmed/41101309 https://www.cell.com/cell/pdf/S0092-8674   Structural Elements of a Chimeric Antigen Receptor Introduction : This is a very LONG blog. It deals with complex issues that I tried to put into context. The “Discussion” section at the end of the blog summarizes the issues and may be easier to d

Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study. Yoon H, Gerdes LA, Beigel F, et al. Proc Natl Acad Sci U S A 2025;122: e2419689122.   Identical Twins Discordant for MS Introduction : Research on finding a “cure” for MS has mostly involved studies of the immune system. While the immune system plays a major role in the disease, and great success has been achieved

Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis R. B. Ionescu, A. M....

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis B. L. L. Clayton, L. Barbar, M. Sapar, K. Kalpana, C. Rao, B....